A former FBI boss has been named special counsel to oversee an inquiry into Russia's alleged meddling in the election and any Trump campaign ties.
In naming Robert Mueller, the deputy attorney general said it was in the public interest to have an outsider.
The appointment has been widely praised by politicians from both sides.
Calls for a special prosecutor had mounted since President Donald Trump fired the most recent FBI director, James Comey, last week.
The FBI and Congress are looking into potential links between Mr Trump's campaign team and Russia.
US intelligence agencies believe Moscow tried to tip the election in favour of the Republican.
Just over an hour after the news of Mr Mueller's appointment emerged, President Trump predicted the new investigation would clear him and his team. Previously, the White House had said there was no need for an outsider to lead an inquiry.
"A thorough investigation will confirm what we already know - there was no collusion between my campaign and any foreign entity," said the president.
The top Democrat in the Senate, Chuck Schumer, said Mr Mueller was "exactly the right kind of individual for this job".
And Republican House Oversight Committee Chairman, Jason Chaffetz, said he had "impeccable credentials".
In his statement announcing the move, Deputy Attorney General Rod Rosenstein said: "The public interest requires me to place this investigation under the authority of a person who exercises a degree of independence from the normal chain of command."
Mr Mueller, who will have wide-ranging powers, said simply: "I accept this responsibility and will discharge it to the best of my ability.''(Source: BBC)